Description

Norleual is a potent and selective inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinases like MMP-2 and MMP-9. This compound is a critical research tool for studying the role of these enzymes in physiological and pathological processes such as tissue remodeling, cancer metastasis, and inflammatory diseases. It is essential for researchers and developers in the fields of pharmaceutical R&D, biochemistry, and oncology who require high-purity biochemicals for target validation and mechanism-of-action studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-9 in cell-based assays and enzymatic studies.
• Oncology Research: Investigated for its potential to inhibit tumor invasion and metastasis by blocking MMP-mediated degradation of the extracellular matrix.
• Neuroscience Research: Applied in models of neuroinflammation and neurodegenerative diseases where MMP activity is implicated in blood-brain barrier disruption and neuronal damage.
• Cardiovascular Disease Models: Utilized in research exploring the role of MMPs in vascular remodeling, atherosclerosis, and aneurysm formation.
• Inflammatory Disease Studies: Employed to probe MMP involvement in conditions such as arthritis, periodontal disease, and chronic wounds.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the design and screening of novel therapeutic MMP inhibitors.

Basic Information

Product Name	Norleual
CAS No.	334994-34-2
Molecular Formula	C₂₀H₃₀N₄O₄
Molecular Weight	390.48 g/mol
Synonyms	Norleual; MMP-2/MMP-9 Inhibitor I; (2S)-N-Hydroxy-1-[(2S)-2-(hydroxyamino)-2-oxo-1-(phenylmethyl)ethyl]-4-methyl-2-[(2-phenylethyl)amino]pentanamide; CAS 334994-34-2; MMP Inhibitor Norleual; MMP-2 Inhibitor Norleual; GM 6001 analog; Ilomastat analog
EINECS	Contact for details

Quality Control

Our Norleual is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and structural confirmation via mass spectrometry (MS) and nuclear magnetic resonance (NMR). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.