Description

5-Fluoro-2-(2,2,2-trifluoroethoxy)aniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of fluorine atoms and the aniline functional group, which is essential for modulating the biological activity and physicochemical properties of target molecules. This high-purity intermediate is primarily required by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine substituents enhance metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display applications.
• Functional Material Development: Employed in creating specialized polymers and dyes with tailored properties like chemical resistance and optical clarity.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Buchwald-Hartwig amination, to introduce complex aniline motifs into molecular architectures.

Basic Information

Product Name	5-Fluoro-2-(2,2,2-trifluoroethoxy)aniline
CAS No.	334929-99-6
Molecular Formula	C8H7F4NO
Molecular Weight	209.14 g/mol
Synonyms	2-Amino-4-fluoro-1-(2,2,2-trifluoroethoxy)benzene; 5-Fluoro-2-(2,2,2-trifluoroethoxy)benzenamine; 1-(2,2,2-Trifluoroethoxy)-4-fluoro-2-aminobenzene; 4-Fluoro-2-(2,2,2-trifluoroethoxy)aniline; 5-Fluoro-2-(trifluoroethoxy)aniline; 334929-99-6; 5-Fluoro-2-(2,2,2-trifluoroethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(2,2,2-trifluoroethoxy)aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.