Description

α-Synuclein (71-82) (Human) CAS NO 332867-16-0 is a defined peptide fragment corresponding to residues 71-82 of the human α-synuclein protein. This high-purity synthetic peptide is a critical research tool for investigating protein aggregation mechanisms, neurotoxicity, and the molecular pathology underlying Parkinson's disease and other synucleinopathies. It is essential for researchers and developers in neuroscience, pharmaceutical discovery, and diagnostic assay development who require precise, well-characterized biomolecules for in vitro and in vivo studies.

Application

• Biochemical Research: Used as a standard or substrate in studies of α-synuclein aggregation kinetics, fibril formation, and oligomer toxicity.
• Antigen Production: Serves as an immunogen for generating specific antibodies targeting the central region of the α-synuclein protein for immunohistochemistry and ELISA.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) assays to identify and validate compounds that inhibit or modulate the aggregation of α-synuclein fragments.
• Diagnostic Development: Utilized as a critical component in the development and calibration of diagnostic tests for detecting α-synuclein-related biomarkers in biological fluids.
• Structure-Activity Relationship (SAR) Studies: Provides a defined sequence for investigating the contribution of specific residues to the protein's function and pathological behavior.
• Cell Culture & In Vitro Models: Applied in cellular models to induce or study α-synuclein-related pathology and to test neuroprotective agents.

Basic Information

Product Name	α-Synuclein (71-82) (Human)
CAS No.	332867-16-0
Molecular Formula	C58H94N18O19
Molecular Weight	1323.5 g/mol
Synonyms	α-Synuclein (71-82); α-Synuclein (71-82); Human α-Synuclein Fragment 71-82; AS (71-82); SNCA (71-82); H2N-VTGVTAVAQKTV-CONH2; Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-amide
EINECS	Contact for details

Quality Control

Every batch of α-Synuclein (71-82) (Human) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by HPLC, MS (Mass Spectrometry), and amino acid analysis. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each product to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.