Description

5-(4-Chloro-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid Hydrazide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new chemical entities for drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory conditions, or as kinase inhibitors.
• Agrochemical Research: Serves as a structural motif in the development of new pesticides or herbicides, leveraging the biological activity of the pyrazolopyrimidine core.
• Chemical Biology & Proteomics: Used as a specialized reagent or probe in biochemical research to study enzyme interactions and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under GMP conditions for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic chemistry and medicinal chemistry programs.
• Material Science Exploration: Investigated as a potential monomer or additive for creating specialty polymers with unique thermal or optical properties.

Basic Information

Product Name	5-(4-Chloro-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid Hydrazide
CAS No.	332859-31-1
Molecular Formula	C14H12ClF3N5O
Molecular Weight	358.73 g/mol
Synonyms	5-(4-Chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-2-carbohydrazide; 5-(4-Chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[1,5-a]pyrimidine-2-carbohydrazide; 332859-31-1; 5-(4-Chloro-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid Hydrazide; 5-(4-Chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid hydrazide; 5-(4-Chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid hydrazide; Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 5-(4-chlorophenyl)-4,5,6,7-tetrahydro-7-(trifluoromethyl)-, hydrazide
EINECS	Contact for details

Quality Control

Our 5-(4-Chloro-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.