Description

5-(p-Tolyl)-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is a high-value, heterocyclic carboxylic acid derivative featuring a fused pyrazolopyrimidine core. This compound is a critical advanced pharmaceutical intermediate (API intermediate) prized for its unique molecular architecture, which combines a trifluoromethyl group for enhanced metabolic stability and lipophilicity with a versatile carboxylic acid handle for further derivatization. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable carboxylic acid functional group.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors or receptor modulators for biological pathway investigation.
• Agrochemical Synthesis: Potential intermediate in the development of advanced pesticides or herbicides leveraging its heterocyclic structure.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands for catalysts or functional organic materials.

Basic Information

Product Name	5-(p-Tolyl)-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid
CAS No.	332858-81-8
Molecular Formula	C15H14F3N3O2
Molecular Weight	325.29 g/mol
Synonyms	5-(4-Methylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 4,5,6,7-Tetrahydro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 7-(Trifluoromethyl)-5-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 332858-81-8; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 5-(p-Tolyl)-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.