Description

Fmoc-(R)-3-Amino-4,4-Diphenyl-Butyric Acid CAS NO 332062-10-9 is a high-purity, non-natural amino acid derivative featuring a chiral center and the Fmoc protecting group. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of a bulky, hydrophobic diphenyl moiety. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutic peptides and investigating protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral amino acid component for the automated synthesis of custom peptides with specific structural features.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, hormone analogs, and enzyme inhibitors.
• Peptidomimetic Design: Incorporates a rigid, hydrophobic scaffold to mimic protein secondary structures and enhance metabolic stability.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating labeled peptides or affinity probes for biochemical assays.
• Academic Research: Employed in studies of chiral recognition, molecular self-assembly, and as a standard in analytical method development.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4,4-Diphenyl-Butyric Acid
CAS No.	332062-10-9
Molecular Formula	C31H27NO4
Molecular Weight	477.55 g/mol
Synonyms	Fmoc-(R)-3-Amino-4,4-diphenylbutanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4,4-diphenyl-(R)-butyric Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-diphenylpropanoic Acid; Fmoc-Diphenylalanine derivative; Fmoc-Amino-4,4-diphenylbutyric Acid; Nα-Fmoc-(R)-3-amino-4,4-diphenylbutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4,4-Diphenyl-Butyric Acid is manufactured under strict quality systems to ensure high chemical and chiral purity suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended within the primary container. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.