Description

H-D-B-Hoala(1-Naphthyl)-Oh.Hcl is a specialized chiral amino acid derivative, specifically a protected naphthylalanine hydrochloride salt. This compound is a high-value building block critical for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for the development of novel peptide-based therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to incorporate a sterically hindered, aromatic amino acid analog into peptide chains.
• Protease Inhibitor Development: Acts as a core structural component in the design and development of selective enzyme inhibitors.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of bioactive peptides.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in catalytic asymmetric reactions to induce stereoselectivity.
• Material Science: Potential application in the synthesis of specialty polymers and advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	H-D-B-Hoala(1-Naphthyl)-Oh.Hcl
CAS No.	331847-00-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	H-D-B-Hoala(1-Naphthyl)-OH hydrochloride; D-2-Amino-3-(1-naphthyl)propanoic acid derivative hydrochloride; Boc-D-1-Nal-OH.HCl; N-tert-Butoxycarbonyl-D-1-naphthylalanine hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)-3-(naphthalen-1-yl)propanoic acid hydrochloride; Boc-D-1-Naphthylalanine HCl; Protected D-1-Nal-OH hydrochloride salt
EINECS	Contact for details

Quality Control

Every batch of H-D-B-Hoala(1-Naphthyl)-Oh.Hcl is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. A Certificate of Analysis (COA) detailing specifications such as chiral purity (HPLC), assay, and residual solvent levels is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.