Description

(R)-3-Amino-4-(2-Methylphenyl)-Butyric Acid-Hcl CAS NO 331846-92-5 is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical synthesis. Its core value lies in its role as a key chiral building block for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of enzyme inhibitors and receptor modulators. This high-purity intermediate is essential for research and production chemists in the pharmaceutical and biotechnology industries who require enantiomerically pure components for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Serves as a constrained amino acid analog for designing and synthesizing novel peptide-like molecules with enhanced stability and bioavailability.
• Enzyme Inhibitor Development: Used in the construction of selective inhibitors for proteases and other enzymes, leveraging its specific stereochemistry and functional groups.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Chemical Biology Probes: Incorporated into molecular probes to study biological pathways and protein function, benefiting from its defined (R)-configuration.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research institutions for custom synthesis projects requiring high-purity, specialized amino acid derivatives.

Basic Information

Product Name	(R)-3-Amino-4-(2-Methylphenyl)-Butyric Acid Hydrochloride
CAS No.	331846-92-5
Molecular Formula	C11H15NO2 • HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	(R)-3-Amino-4-(o-tolyl)butanoic acid hydrochloride; (R)-3-Amino-4-(2-methylphenyl)butyric acid HCl; (R)-2-Methyl-β-homophenylalanine hydrochloride; (R)-3-Amino-4-(2-methylphenyl)butanoic acid hydrochloride; (R)-β-Homo-2-methylphenylalanine HCl; BA 1237; (R)-HMPA-HCl
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-4-(2-Methylphenyl)-Butyric Acid-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.