Description

Fmoc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a fluoro-phenyl side chain and an Fmoc-protected amine, essential for constructing complex peptide architectures. This chiral building block is critical for medicinal chemistry research, enabling the synthesis of peptide-based drug candidates with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in peptide synthesis and the development of novel therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the automated synthesis of complex peptides containing fluorinated aromatic residues.
• Peptidomimetic Drug Discovery: Used to incorporate fluorinated, non-natural amino acids into peptide backbones to improve pharmacokinetic properties like bioavailability and proteolytic stability.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of targeted therapies, including enzyme inhibitors and receptor modulators.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Custom Peptide Services: A fundamental reagent for contract research organizations (CROs) and CDMOs offering bespoke peptide manufacturing.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis, peptide chemistry, and medicinal chemistry.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid
CAS No.	331763-63-4
Molecular Formula	C25H22FNO4
Molecular Weight	419.45 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(2-fluorophenyl)butanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2-fluorophenyl)butanoic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-fluorophenyl)butanoic Acid; Fmoc-D-2-Fluoropheg-OH; Fmoc-(R)-2-Fluoropheg-OH; Fmoc-(R)-4-(2-Fluorophenyl)-3-aminobutanoic Acid; N-α-Fmoc-3-amino-4-(2-fluorophenyl)butyric Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(2-Fluoro-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and chemical purity, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.