Description

(4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-5-Methylhexanoic Acid is a high-purity, non-natural amino acid derivative featuring the Fmoc (9-fluorenylmethoxycarbonyl) protecting group. This compound matters as a critical, chiral building block for the controlled synthesis of complex peptides and peptidomimetics, enabling advanced research and development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on developing novel therapeutic peptides, proteomics research, and creating specialized chemical libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the controlled, sequential assembly of peptides using Fmoc-chemistry protocols.
• Peptidomimetic Drug Discovery: Used to incorporate non-standard, methyl-branched amino acid structures into novel drug candidates to enhance metabolic stability and binding affinity.
• Chemical Biology Research: Employed in the synthesis of labeled peptides, activity-based probes, and protein interaction inhibitors for mechanistic studies.
• Combinatorial Library Synthesis: Serves as a valuable building block for generating diverse arrays of peptide-like compounds for high-throughput screening.
• API (Active Pharmaceutical Ingredient) Development: Used in the research-scale synthesis of potential peptide-based active ingredients.
• Bioconjugation: The carboxylic acid moiety allows for further functionalization and conjugation to other molecules or surfaces.

Basic Information

Product Name	(4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-5-Methylhexanoic Acid
CAS No.	331763-51-0
Molecular Formula	C23H25NO5
Molecular Weight	395.45 g/mol
Synonyms	Fmoc-(R)-4-Amino-5-methylhexanoic Acid; Fmoc-4-Amino-5-methyl-(R)-hexanoic Acid; (R)-4-(Fmoc-Amino)-5-methylhexanoic Acid; 4-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-5-methyl-(4R)-hexanoic acid; Fmoc-AMH-OH; Fmoc-D-4-Amino-5-methylhexanoic acid; N-α-Fmoc-4-amino-5-methyl-L-norleucine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-5-Methylhexanoic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.