Description

Ethyl 4-(2,3-Dimethoxyphenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyrimidinone class of compounds. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its defined stereochemistry and structural complexity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Integral in the production route for complex molecules where the dihydropyrimidinone core is a required pharmacophore.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Organic Synthesis Building Block: Utilized in academic and industrial research for constructing novel heterocyclic compounds with potential biological activity.

Basic Information

Product Name	Ethyl 4-(2,3-Dimethoxyphenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate
CAS No.	331235-66-6
Molecular Formula	C₁₆H₂₀N₂O₅
Molecular Weight	320.34 g/mol
Synonyms	Ethyl 4-(2,3-dimethoxyphenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(2,3-dimethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; 4-(2,3-Dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; DHPM derivative; Biginelli reaction product; Dihydropyrimidinone derivative.
EINECS	Contact for details

Quality Control

Our Ethyl 4-(2,3-Dimethoxyphenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure it meets the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.