Description

2-(4-Methyl-6-Piperazin-1-Ylpyrimidin-2-Yl)Phenol (Hydrochloride Salt) is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced antiviral active pharmaceutical ingredients (APIs), particularly those targeting HIV-1. It is essential for research institutions, custom synthesis laboratories, and pharmaceutical manufacturers engaged in the development and production of next-generation antiviral therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the manufacture of non-nucleoside reverse transcriptase inhibitor (NNRTI) class antiviral drugs.
• Antiviral API Synthesis: Used in the research, development, and scale-up production of active pharmaceutical ingredients (APIs) for HIV-1 treatment regimens.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of novel antiviral agents.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and process optimization projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Item	Details
Product Name	2-(4-Methyl-6-Piperazin-1-Ylpyrimidin-2-Yl)Phenol (Hydrochloride Salt)
CAS No.	330982-03-1
Molecular Formula	C15H19N4O·HCl
Molecular Weight	308.80 g/mol
Synonyms	2-(4-Methyl-6-(piperazin-1-yl)pyrimidin-2-yl)phenol hydrochloride; 2-(4-Methyl-6-piperazin-1-yl-pyrimidin-2-yl)-phenol hydrochloride; Phenol, 2-[4-methyl-6-(1-piperazinyl)-2-pyrimidinyl]-, hydrochloride (1:1); NNRTI Intermediate; R120758 (related base compound); A non-nucleoside reverse transcriptase inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our 2-(4-Methyl-6-Piperazin-1-Ylpyrimidin-2-Yl)Phenol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards required for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability, consistency, and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.