Description

3-[(6-Chloro-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of targeted small-molecule therapeutics, particularly kinase inhibitors. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel drug candidates for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors and other biologically active quinazoline derivatives.
• Oncology Drug Discovery: Serves as a core scaffold for the research and development of targeted cancer therapies that interfere with specific cellular signaling pathways.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and structure-activity relationship (SAR) studies.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material and commercial API production.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects exploring new heterocyclic compounds with therapeutic potential.

Basic Information

Product Name	3-[(6-Chloro-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid
CAS No.	330950-71-5
Molecular Formula	C21H14ClN3O2
Molecular Weight	375.81 g/mol
Synonyms	3-[(6-Chloro-4-phenylquinazolin-2-yl)amino]benzoic acid; 2-[(3-Carboxyphenyl)amino]-6-chloro-4-phenylquinazoline; 6-Chloro-2-[(3-carboxyphenyl)amino]-4-phenylquinazoline; Benzoic acid, 3-[(6-chloro-4-phenyl-2-quinazolinyl)amino]-; 330950-71-5; 3-(6-Chloro-4-phenylquinazolin-2-ylamino)benzoic acid
EINECS	Contact for details

Quality Control

Our 3-[(6-Chloro-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.