Description

Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]Glycylglycylglycylglycyl- is a specialized Boc-protected tetraglycine peptide building block, essential for precise and efficient solid-phase peptide synthesis (SPPS). Its primary value lies in providing a protected, high-purity fragment that streamlines the assembly of complex peptide sequences, minimizing side reactions and improving overall yield. This compound is critically needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled elongation of peptide chains in automated synthesizers.
• Pharmaceutical Research: Building block for the discovery and development of new peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to create peptide tags or spacers for linking biomolecules in antibody-drug conjugates (ADCs) or diagnostic probes.
• Biochemical Reagent Production: Synthesis of substrates, inhibitors, or standards for enzymatic assays and proteomics research.
• Material Science: Incorporation into bio-inspired polymers and hydrogels for biomedical applications.

Basic Information

Product Name	Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]Glycylglycylglycylglycyl-
CAS No.	330807-97-1
Molecular Formula	C17H28N6O8
Molecular Weight	444.44 g/mol
Synonyms	Boc-Gly-Gly-Gly-Gly-OH; Boc-Gly4-OH; Boc-GGGG-OH; (tert-Butoxycarbonyl)glycylglycylglycylglycine; N-(tert-Butoxycarbonyl)tetraglycine; 2-[(2-[(2-[(2-{[(tert-butoxy)carbonyl]amino}acetyl)amino]acetyl)amino]acetyl)amino]acetic acid; Boc-Gly-Gly-Gly-Gly; Tetraglycine Boc-hydrazide precursor
EINECS	Contact for details

Quality Control

Our Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]Glycylglycylglycylglycyl- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific pharmacopeial requirements (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥95.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.