Description

Urocortin Ii (Mouse) is a synthetic peptide analog of the endogenous corticotropin-releasing factor (CRF) family, specifically the mouse variant. This compound is a critical research tool for investigating the stress response system, energy homeostasis, and related neurological pathways. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on endocrinology, neurobiology, and metabolic disorders.

Application

• Neuroscientific Research: Used as a selective CRF receptor type 2 (CRF2) agonist to study anxiety, depression, and stress-related behaviors in rodent models.
• Endocrinology Studies: Investigates the role of urocortin peptides in the hypothalamic-pituitary-adrenal (HPA) axis and their effects on hormone release.
• Cardiovascular Research: Explores the cardioprotective effects and hemodynamic responses mediated by CRF2 receptor activation.
• Metabolic Disorder Research: Applied in studies examining appetite suppression, energy expenditure, and potential therapeutic avenues for obesity.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and lead optimization for CNS and metabolic targets.
• In Vitro Assay Development: Utilized in cell-based assays (e.g., cAMP accumulation, calcium flux) to characterize receptor binding and signal transduction.

Basic Information

Product Name	Urocortin Ii (Mouse)
CAS No.	330648-32-3
Molecular Formula	C198H310N56O55S2
Molecular Weight	4388.1 g/mol
Synonyms	Mouse Urocortin II; mUCN II; Urocortin-2 (mouse); Stresscopin-related peptide; SCP; CRF2 Receptor Agonist; hUcnII (mouse variant); Ucn 2 (mouse)
EINECS	Contact for details

Quality Control

Our Urocortin Ii (Mouse) is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, which includes data from HPLC for purity assessment, Mass Spectrometry (MS) for identity confirmation, and Amino Acid Analysis (AAA). We adhere to high-purity peptide standards to ensure reliable and reproducible research outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Once reconstituted in a suitable buffer (e.g., sterile 0.1% acetic acid or PBS), aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Amino Acid Sequence	IKDTLSNLRTLLLFLTRSKRELRQEQQAARAAARLQRAQQAHSNRKLMEII
Molecular Weight	4388.1 ± 1.0 Da
Solubility	Soluble in water, acetic acid (0.1%), or PBS
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.