Description

Tau Peptide (301-315) CAS NO 330456-48-9 is a synthetic peptide fragment corresponding to amino acid residues 301-315 of the human tau protein. This specific sequence is of significant interest in neurological research for its role in protein aggregation studies. It serves as a critical tool for researchers investigating the molecular mechanisms underlying tauopathies, including Alzheimer's disease. The peptide is essential for biochemical assays, antibody development, and as a reference standard in diagnostic applications.

Application

• Neuroscience Research: Used as a key antigen and reference standard in studies of tau protein aggregation, phosphorylation, and neurofibrillary tangle formation.
• Antibody Production & Validation: Serves as an immunogen for generating monoclonal and polyclonal antibodies specific to the tau protein epitope.
• Diagnostic Assay Development: Employed in the development and calibration of ELISA, Western blot, and other immunoassays for detecting tau-related biomarkers.
• Drug Discovery Screening: Acts as a target substrate in high-throughput screening platforms to identify potential therapeutic compounds that inhibit abnormal tau interactions.
• Biochemical & Biophysical Studies: Utilized in structural analysis, binding affinity measurements, and in vitro modeling of tau protein behavior.

Basic Information

Product Name	Tau Peptide (301-315)
CAS No.	330456-48-9
Molecular Formula	C73H115N21O23S
Molecular Weight	1630.88 g/mol
Synonyms	Tau (301-315) Peptide; Tau Protein Fragment 301-315; H-Tyr-Lys-Val-Val-Gln-Ile-Ile-Asn-Lys-His-Lys-Thr-Leu-Met-OH; YKVQIIHKKTDLM; Human Tau Peptide (301-315); pTau Peptide (301-315) (for phosphorylated variants); Neurofibrillary Tangle Associated Tau Peptide; Alzheimer's Disease Research Peptide
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (301-315) is manufactured and analyzed under stringent quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and endotoxin levels are provided with each shipment to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	1630.88 ± 2 Da
Amino Acid Composition	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.