Description

Tau Peptide (337-368) (Repeat 4 Domain) is a synthetic peptide fragment corresponding to a specific microtubule-binding repeat region of the human tau protein. This compound is of significant value for researchers studying the molecular mechanisms of tauopathies, including Alzheimer's disease. It serves as a critical biochemical tool for applications in neuroscience, pharmaceutical development, and diagnostic research, enabling the study of tau aggregation, protein-protein interactions, and antibody epitope mapping.

Application

• Neuroscience Research: Fundamental studies on tau protein function, microtubule assembly/disassembly dynamics, and neuronal cytoskeleton integrity.
• Drug Discovery & Development: Screening and validation of therapeutic candidates designed to inhibit pathological tau aggregation or modulate tau phosphorylation.
• Diagnostic Assay Development: Used as a critical antigen for the production and calibration of antibodies in ELISA, Western blot, and immunohistochemistry assays for tau detection.
• Biomarker Research: Investigation of tau fragments as potential biomarkers in cerebrospinal fluid (CSF) or blood-based assays for neurodegenerative diseases.
• Structural Biology Studies: NMR, X-ray crystallography, and other biophysical techniques to elucidate the structure of tau repeat domains and their interactions.
• Academic & Institutional Research: A key reagent for laboratories focused on neurodegenerative disease mechanisms and cell biology.

Basic Information

Product Name	Tau Peptide (337-368) (Repeat 4 Domain)
CAS No.	330456-27-4
Molecular Formula	C152H246N44O47S
Molecular Weight	~3430.9 g/mol
Synonyms	Tau Protein Fragment (337-368); Microtubule-Associated Protein Tau (337-368); Tau Repeat Domain Peptide (R4); hTau(337-368); MAPT (337-368) Peptide; Tau Peptide R4; 4-Repeat Tau Peptide (337-368); Synthetic Tau Repeat 4 Domain
EINECS	Contact for details

Quality Control

Our Tau Peptide (337-368) (Repeat 4 Domain) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) providing detailed results for purity, identity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.