Description

Tau Peptide (275-305) (Repeat 2 Domain) CAS NO 330456-25-2 is a synthetic peptide fragment corresponding to the microtubule-binding repeat region of the human tau protein. This specific sequence is critical for research into tau protein aggregation, misfolding, and its role in neurodegenerative pathologies. It serves as an essential biochemical tool for neuroscientists, biochemists, and pharmaceutical R&D teams focused on Alzheimer's disease and related tauopathies. The high-purity peptide enables precise in vitro studies, antibody development, and screening for therapeutic interventions.

Application

• Biochemical Research: Used as a key reagent in studies investigating tau protein aggregation kinetics, filament formation, and structure-function relationships.
• Antibody Production & Epitope Mapping: Serves as a critical antigen for generating and characterizing monoclonal and polyclonal antibodies specific to the tau repeat 2 domain.
• Drug Discovery Screening: Employed in high-throughput and secondary assay platforms to identify and validate small molecules or biologics that inhibit tau aggregation.
• Diagnostic Development: Utilized in the development and calibration of immunoassays (ELISA, Western Blot) for detecting pathological tau species in research settings.
• Neuroscience Model Systems: Applied in cell-based models to study tau toxicity, phosphorylation, and cellular trafficking mechanisms.
• Reference Standard: Acts as a purified quantitative standard for mass spectrometry, chromatography, and other analytical techniques in proteomics research.

Basic Information

Product Name	Tau Peptide (275-305) (Repeat 2 Domain)
CAS No.	330456-25-2
Molecular Formula	C144H238N44O47S
Molecular Weight	~3290.8 g/mol
Synonyms	Tau Protein Fragment (275-305); Microtubule-Associated Protein Tau (275-305); Tau Repeat Domain 2 Peptide; MAPT (275-305); hTau44 (275-305); Aggregation-Prone Tau Peptide; Tau R2 Peptide; Synthetic Tau Peptide
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (275-305) (Repeat 2 Domain) is manufactured under controlled conditions and undergoes rigorous analytical characterization to ensure identity, purity, and consistency. Quality is verified by multiple orthogonal methods including HPLC, MS, and amino acid analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our quality system supports research requiring high-purity, well-defined biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Molecular Weight (MS)	Within ±1 Da of theoretical
Solubility	Soluble in water or aqueous buffer
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.