Description

Tau Peptide (244-274) (Repeat 1 Domain) CAS NO 330456-24-1 is a synthetic peptide fragment corresponding to a specific microtubule-binding repeat region of the human tau protein. This high-purity biochemical is a critical research tool for studying the molecular mechanisms of tauopathies, including Alzheimer's disease. It is essential for scientists and pharmaceutical developers in neuroscience research, diagnostic assay development, and drug discovery programs targeting tau aggregation and neurofibrillary tangle formation.

Application

• Biochemical Research: Used as a key antigen and standard in studies of tau protein structure, function, and aggregation kinetics.
• Antibody Production & Validation: Serves as an immunogen for generating and characterizing tau-specific monoclonal and polyclonal antibodies.
• Diagnostic Development: Employed in the development and calibration of ELISA, Western blot, and other immunoassays for detecting tau and its fragments.
• Drug Discovery Screening: Acts as a target substrate in high-throughput screens for inhibitors of tau phosphorylation, aggregation, or filament formation.
• Cell Culture & In Vitro Studies: Used to investigate the effects of specific tau domains on microtubule dynamics and cellular toxicity.
• Reference Standard: Provides a characterized standard for quality control in research and diagnostic kit manufacturing.

Basic Information

Product Name	Tau Peptide (244-274) (Repeat 1 Domain)
CAS No.	330456-24-1
Molecular Formula	C152H246N44O47S
Molecular Weight	~3430.9 g/mol
Synonyms	Tau (244-274) peptide; Microtubule-associated protein tau fragment 244-274; Tau protein repeat 1 domain peptide; MAPT (244-274); hTau244-274; Tau R1 peptide; Alzheimer's disease tau peptide; Paired helical filament (PHF) tau peptide (244-274)
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (244-274) is manufactured and analyzed under stringent conditions to ensure the highest standards of identity, purity, and consistency. Our products undergo rigorous quality testing, including HPLC, MS, and amino acid analysis. Certificates of Analysis (COA) detailing purity, molecular weight confirmation, and endotoxin levels are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. Aliquot into single-use vials to minimize freeze-thaw cycles and exposure to air.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	3428 - 3434 Da
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.