Description

Fmoc-1-Amino-1-Cyclodecanecarboxylic Acid is a specialized, high-purity building block designed for advanced peptide synthesis and medicinal chemistry research. This compound is valued for its unique, conformationally constrained cyclodecane backbone, which is critical for introducing specific structural motifs into target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative, it serves as a key monomer for the controlled assembly of complex peptide chains.
• Peptidomimetic Drug Discovery: The rigid, medium-sized ring structure is used to mimic peptide secondary structures, enhancing metabolic stability and bioavailability in drug candidates.
• Combinatorial Chemistry Libraries: Employed to create diverse libraries of cyclic and constrained peptides for high-throughput screening against biological targets.
• Bioconjugation and Probe Development: Useful for synthesizing labeled peptides or peptide-based probes for diagnostic and biochemical research applications.
• Academic and Industrial Research: A fundamental reagent for studying structure-activity relationships (SAR) in peptide science and bioorganic chemistry.

Basic Information

Product Name	Fmoc-1-Amino-1-Cyclodecanecarboxylic Acid
CAS No.	329790-80-9
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-1-Amino-1-cyclodecanecarboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclodecane-1-carboxylic acid; Fmoc-Acd-OH; Fmoc-1-Aminocyclodecanecarboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-aminocyclodecanecarboxylic acid; 1-(Fmoc-amino)cyclodecanecarboxylic acid; N-Fmoc-1-amino-1-cyclodecanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-1-Amino-1-Cyclodecanecarboxylic Acid is produced under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.