Description

3-Nitro-5-(2,2,2-Trifluoro-Ethoxy)Phenylamine is a specialized aromatic amine derivative featuring a nitro group and a trifluoroethoxy substituent. This compound matters as a high-value pharmaceutical intermediate and agrochemical building block, where its unique fluorine-containing structure imparts critical properties to final active ingredients. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, crop protection, and advanced materials sectors for synthesizing novel molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoroethoxy group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, leveraging its aromatic and fluorine content.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for constructing complex nitro- and amino-substituted aromatic systems.
• Dye and Pigment Intermediate: Acts as a precursor in the manufacture of specialized azo dyes and colorants.
• Cross-Coupling Reactions: Useful substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating novel chemical entities.

Basic Information

Item	Details
Product Name	3-Nitro-5-(2,2,2-Trifluoro-Ethoxy)Phenylamine
CAS No.	329782-05-0
Molecular Formula	C8H7F3N2O3
Molecular Weight	236.15 g/mol
Synonyms	3-Nitro-5-(2,2,2-trifluoroethoxy)aniline; 5-Amino-3-nitro-1-(2,2,2-trifluoroethoxy)benzene; 2,2,2-Trifluoroethyl 3-amino-5-nitro phenyl ether; 3-Amino-5-nitro-α,α,α-trifluorophenetole; 3-Nitro-5-(trifluoroethoxy)benzenamine; 5-(2,2,2-Trifluoroethoxy)-3-nitroaniline; 3-Nitro-5-(trifluoroethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our 3-Nitro-5-(2,2,2-Trifluoro-Ethoxy)Phenylamine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.