Description

5-Bromo-2-(Difluoromethoxy)Benzaldehyde is a versatile and high-value aromatic aldehyde building block, distinguished by its bromine and difluoromethoxy substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the difluoromethoxy group for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a core structure in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Organic Synthesis Building Block: The aldehyde group is a versatile handle for further functionalization via condensation, reduction, or oxidation reactions.
• Chemical Research & Development: Used in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Bromo-2-(Difluoromethoxy)Benzaldehyde
CAS No.	329269-64-9
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	5-Bromo-2-(difluoromethoxy)benzaldehyde; 2-(Difluoromethoxy)-5-bromobenzaldehyde; 5-Bromo-α,α-difluoro-o-anisaldehyde; Benzaldehyde, 5-bromo-2-(difluoromethoxy)-; 329269-64-9; 5-Bromo-2-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Difluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its easily oxidized nature, minimize headspace and exposure to air after opening. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.