Description

Fmoc-cis-1,4-Aminocyclohexyl Acetic Acid CAS NO 327156-95-6 is a protected amino acid derivative featuring a rigid cyclohexyl backbone. This compound is a critical building block (Fmoc-protected amino acid) in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a conformationally constrained, cis-oriented 1,4-diaminocyclohexyl moiety into peptide chains. It is primarily required by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and bioactive compounds where structural rigidity and specific stereochemistry are essential for biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: In the research and development of novel peptide-based drugs and therapeutic agents.
• Peptidomimetic Design: For creating non-natural peptide analogs with enhanced metabolic stability and receptor selectivity.
• Bioconjugation & Probe Development: As a specialized component for labeling proteins or creating molecular probes.
• Chemical Biology Research: For studying protein-protein interactions and enzyme mechanisms using synthetic peptide substrates.
• Custom Peptide Services: Used by CROs and CDMOs to produce client-specified peptide sequences for pre-clinical studies.

Basic Information

Product Name	Fmoc-cis-1,4-Aminocyclohexyl Acetic Acid
CAS No.	327156-95-6
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	Fmoc-cis-1,4-ACHA-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-cis-1,4-cyclohexanediamine-N-acetic Acid; (cis-4-[(Fmoc-amino)methyl]cyclohexyl)acetic Acid; Fmoc-Cis-1,4-Acha; Fmoc-1,4-cis-Aminocyclohexylacetic Acid; Nα-Fmoc-cis-1,4-diaminocyclohexane-Nβ-acetic Acid; (1R,4S)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethyl]cyclohexaneacetic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-cis-1,4-Aminocyclohexyl Acetic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.