Description

4'-Aminomethyl-5-Fam CAS NO 326802-08-8 is a specialized fluorescent dye derivative, specifically a functionalized fluorescein (FAM) compound. This product is critical for researchers and manufacturers requiring high-purity, reactive intermediates for advanced bioconjugation and labeling applications. It is primarily utilized in the life sciences sector for developing sensitive diagnostic assays, probes for cellular imaging, and novel pharmaceutical research tools.

Application

• Fluorescent Labeling Reagent: Acts as a key intermediate for synthesizing active esters (e.g., NHS esters) used to label proteins, antibodies, peptides, and oligonucleotides.
• Diagnostic Assay Development: Essential for manufacturing fluorescent probes and tracers used in ELISA, flow cytometry, and fluorescence in situ hybridization (FISH).
• Bioconjugation & Linker Chemistry: The aminomethyl group provides a versatile handle for conjugation to carboxylic acids, aldehydes, and other functional groups via crosslinking strategies.
• Pharmaceutical Research: Used in the synthesis of drug candidates and targeted therapeutic agents where a fluorescent tag is required for pharmacokinetic and biodistribution studies.
• Sensor & Material Science: Employed in the development of chemical sensors, biochips, and smart materials that respond to specific analytes with a fluorescent signal.
• Academic & Industrial R&D: Serves as a fundamental building block in research laboratories for exploring new bioimaging techniques and molecular detection methods.

Basic Information

Product Name	4'-Aminomethyl-5-Fam
CAS No.	326802-08-8
Molecular Formula	C22H17NO6
Molecular Weight	391.37 g/mol
Synonyms	5(6)-FAM, aminomethyl; 4'-Aminomethylfluorescein; 5-(Aminomethyl)fluorescein; 6-(Aminomethyl)fluorescein; 4'-Aminomethyl-5(6)-carboxyfluorescein; 5-FAM, 4'-aminomethyl derivative; 6-FAM, 4'-aminomethyl derivative; Aminomethyl FAM
EINECS	Contact for details

Quality Control

Our 4'-Aminomethyl-5-Fam is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for sensitive research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.