Description

4-[(Aminocarbonyl)Amino]-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-D-Phenylalanine CAS NO 324017-22-3 is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and orthogonally protected functional groups in complex molecule assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, peptidomimetics, and as a key building block in solid-phase peptide synthesis (SPPS).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled, sequential assembly of custom peptides, particularly those requiring D-configuration amino acids.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Serves as a precursor for creating modified peptide structures with enhanced stability, bioavailability, or target specificity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening against biological targets.
• Bioconjugation and Labeling: The reactive amino and carbonyl groups facilitate site-specific conjugation with other molecules, such as fluorophores or drug payloads.
• Academic and Industrial Research: Essential reagent for studies in medicinal chemistry, chemical biology, and proteomics.

Basic Information

Product Name	4-[(Aminocarbonyl)Amino]-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-D-Phenylalanine
CAS No.	324017-22-3
Molecular Formula	C25H21N3O5
Molecular Weight	443.45 g/mol
Synonyms	Fmoc-D-Phe(4-ureido); Fmoc-4-Ureido-D-phenylalanine; N-α-Fmoc-N-δ-ureido-D-phenylalanine; Fmoc-D-Phe(4-NHCONH2)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-ureidophenyl)propanoic acid; 4-Ureido-D-phenylalanine, N-α-Fmoc derivative; Fmoc-4-(aminocarbonylamino)-D-phenylalanine
EINECS	Contact for details

Quality Control

Our 4-[(Aminocarbonyl)Amino]-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade material requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.