Description

1,2-Dioctanoyl-Sn-Glycero-3-[Phospho-L-Serine](Sodium Salt) is a synthetic, anionic phospholipid derivative that serves as a critical building block and model compound in advanced biochemical research and development. Its value lies in its defined structure, which enables precise studies of lipid-protein interactions, membrane biophysics, and cellular signaling pathways. This high-purity lipid is essential for researchers and formulators in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, well-characterized materials for developing liposomal drug delivery systems, creating synthetic membranes, and studying apoptosis-related processes.

Application

• Liposomal Drug Delivery: A key component for formulating anionic liposomes to encapsulate and deliver therapeutic agents, including nucleic acids (DNA, siRNA) and small molecule drugs.
• Biomembrane Research: Used as a model phospholipid to study membrane dynamics, lipid raft formation, and the behavior of phosphatidylserine (PS) in cellular membranes.
• Cell Signaling & Apoptosis Studies: Employed in research on programmed cell death (apoptosis), where externalization of phosphatidylserine is a key marker.
• Diagnostic Reagent Development: Incorporated into assays and kits for the detection of apoptosis (e.g., Annexin V binding assays) and blood coagulation factors.
• Biomaterial & Coatings: Utilized to create biocompatible surface coatings and functionalized materials that mimic natural cell surfaces.
• Enzyme Substrate: Acts as a specific substrate for phospholipase enzymes in kinetic and mechanistic studies.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-[Phospho-L-Serine](Sodium Salt)
CAS No.	321862-88-8
Molecular Formula	C22H41NNaO10P
Molecular Weight	557.52 g/mol
Synonyms	DOPS (C8:0); 1,2-Di-O-octanoyl-sn-glycero-3-phospho-L-serine sodium salt; L-α-Phosphatidylserine (C8:0); PS(C8:0); 1,2-Dicapryloyl-sn-glycero-3-phosphoserine sodium salt; Octanoyl Phosphatidylserine; Synthetic Phosphatidylserine (C8); sn-Glycero-3-phospho-L-serine, 1,2-dihexanoate sodium salt (related)
EINECS	Contact for details

Quality Control

Our 1,2-Dioctanoyl-Sn-Glycero-3-[Phospho-L-Serine](Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and formulation. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for critical applications in drug delivery and diagnostics.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For extended storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.