Description

Amyloid Bri Protein (1-34) CAS NO 321853-88-7 is a synthetic peptide fragment corresponding to the first 34 amino acids of the Amyloid Bri protein, a key component in Familial British Dementia. This high-purity reference standard is critical for advancing research into neurodegenerative disease mechanisms and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on amyloidosis and related protein aggregation disorders.

Application

• Biomedical Research: A crucial reference standard for studying the aggregation kinetics, neurotoxicity, and pathology of Familial British Dementia (FBD).
• Drug Discovery & Screening: Used in high-throughput assays to identify and validate potential inhibitors of amyloid fibril formation for therapeutic intervention.
• Diagnostic Development: Serves as a key antigen for the development and calibration of immunoassays (ELISA, Western Blot) targeting amyloid Bri protein.
• Structural Biology Studies: Employed in NMR, X-ray crystallography, and other biophysical techniques to elucidate the three-dimensional structure and folding of the peptide.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies against the Bri protein fragment.
• Cellular & Animal Model Studies: Used to induce and model amyloid deposition in vitro and in vivo to study disease progression and treatment efficacy.

Basic Information

Product Name	Amyloid Bri Protein (1-34)
CAS No.	321853-88-7
Molecular Formula	C164H262N48O51S
Molecular Weight	~3770.2 g/mol
Synonyms	ABri (1-34); ABri Peptide (1-34); Amyloid Bri Peptide Fragment 1-34; Bri Protein Fragment (1-34); Familial British Dementia Peptide; pGlu-Asn-Pro-Arg-His-Arg-Ser-Ser-Arg-Phe-Ser-Glu-Val-Arg-His-Leu-Gln-Asp-Ser-Ala-Tyr-Glu-Pro-Val-Tyr-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH; Synthetic ABri (1-34)
EINECS	Contact for details

Quality Control

Every batch of Amyloid Bri Protein (1-34) is manufactured under stringent conditions and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality assurance protocol includes multiple orthogonal methods such as HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ± 10% of theoretical
Molecular Weight (MS)	Within ± 2 Da of theoretical
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.