Description

(1R)-1-(4-Fluorophenyl)-2-Methoxyethan-1-Amine CAS NO 321840-35-1 is a chiral amine building block of significant importance in modern synthetic chemistry. This compound matters because its specific stereochemistry and functional groups make it a versatile intermediate for constructing complex, biologically active molecules. Pharmaceutical research and development organizations need it for the synthesis of potential drug candidates, particularly in areas requiring enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is critical.
• Academic & Contract Research: Essential for methodological development in organic synthesis and medicinal chemistry within academic and CRO (Contract Research Organization) settings.

Basic Information

Product Name	(1R)-1-(4-Fluorophenyl)-2-Methoxyethan-1-Amine
CAS No.	321840-35-1
Molecular Formula	C9H12FNO
Molecular Weight	169.20 g/mol
Synonyms	(R)-1-(4-Fluorophenyl)-2-methoxyethanamine; (1R)-1-(4-Fluorophenyl)-2-methoxyethanamine; (R)-1-(p-Fluorophenyl)-2-methoxyethylamine; (R)-4-Fluoro-α-(methoxymethyl)benzylamine; (R)-2-Methoxy-1-(4-fluorophenyl)ethanamine; (R)-1-(4-Fluorophenyl)-2-methoxy-1-ethanamine; (R)-FMPMEA; (R)-FMEA
EINECS	Contact for details

Quality Control

Our (1R)-1-(4-Fluorophenyl)-2-Methoxyethan-1-Amine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.