Description

(D-Tyr5)-Histrelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) with a D-tyrosine substitution at the fifth position. This modification confers enhanced metabolic stability and specific receptor-binding properties, making it a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) focused on endocrinology, oncology, and the development of novel peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced GnRH agonist and antagonist drug candidates.
• Biomedical Research: Used as a reference standard and active probe in studies of GnRH receptor signaling, structure-activity relationships (SAR), and peptide hormone metabolism.
• Drug Discovery & Development: Employed in preclinical research for the development of treatments targeting hormone-dependent conditions such as prostate cancer, breast cancer, endometriosis, and central precocious puberty.
• Analytical Standard: Essential for method development, validation, and quality control (QC) in analytical laboratories using techniques like HPLC and LC-MS.
• Peptide Chemistry Studies: A valuable compound for investigating the effects of D-amino acid substitutions on peptide conformation, stability, and biological activity.

Basic Information

Product Name	(D-Tyr5)-Histrelin
CAS No.	321709-40-4
Molecular Formula	C₆₆H₈₆N₁₈O₁₂
Molecular Weight	1307.5 g/mol
Synonyms	Histrelin (5-D-Tyrosine); [D-Tyr5]-Histrelin; 5-D-Tyrosine-Histrelin; GnRH Agonist (D-Tyr5) analog; LHRH Agonist analog; Azaline B derivative; (5-D-Tyr)-Histrelin; Des-Gly10, D-Tyr5, Pro9-NHEt-LHRH
EINECS	Contact for details

Quality Control

Our (D-Tyr5)-Histrelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA) that includes results from HPLC for purity, MS for identity confirmation, and amino acid analysis. Specifications are designed to meet the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.