Description

(D-His2)-Triptorelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) with a specific D-histidine substitution at position 2. This structural modification is critical for enhancing its metabolic stability and receptor binding affinity, making it a valuable research-grade compound. It is primarily utilized in advanced pharmaceutical research and development, particularly in the study of hormone-dependent conditions and the development of novel therapeutic agents. The compound is essential for researchers and developers in the fields of endocrinology, oncology, and peptide-based drug discovery.

Application

• Pharmaceutical R&D: Serves as a key reference standard and intermediate in the development of novel GnRH analog therapeutics.
• Biochemical Research: Used in receptor binding studies, signal transduction pathway analysis, and structure-activity relationship (SAR) investigations.
• Endocrinology Studies: Applied in preclinical research to study the regulation of the hypothalamic-pituitary-gonadal axis.
• Oncology Research: Investigated for its potential role in the treatment of hormone-sensitive cancers, such as prostate and breast cancer.
• Peptide Chemistry: Employed as a building block or model compound in synthetic peptide chemistry and process development.
• Analytical Standard: Used as a high-purity standard for method development and validation in analytical laboratories (HPLC, MS).

Basic Information

Product Name	(D-His2)-Triptorelin
CAS No.	321709-34-6
Molecular Formula	C₆₄H₈₂N₁₈O₁₂
Molecular Weight	1311.5 g/mol
Synonyms	D-His(2)-Triptorelin; Triptorelin D-His(2) analog; [D-His²]-Triptorelin; Gonadorelin (5-deoxy-L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-histidyl-L-leucyl-L-arginyl-L-prolyl-glycinamide); Decapeptyl D-His(2) derivative; PGL-His-Trp-Ser-Tyr-D-His-Leu-Arg-Pro-Gly-NH₂; GnRH agonist analog (D-His²)
EINECS	Contact for details

Quality Control

Our (D-His2)-Triptorelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. Our quality commitment supports applications requiring high-purity peptide standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.