Description

n-(2-Chloro-5-Fluoro-4-Pyrimidinyl)-n-Ethylamine is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for research and development chemists seeking to introduce specific halogenated and amine-substituted pyrimidine motifs into complex molecular architectures. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including potential kinase inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyrimidine core for bioactivity.
• Chemical Biology & Medicinal Chemistry: Employed as a versatile scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Organic Synthesis Building Block: Serves as a precursor for further functionalization (e.g., cross-coupling reactions, nucleophilic substitutions) to create more complex heterocyclic compounds.
• Material Science Research: Potential monomer or functional component in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	n-(2-Chloro-5-Fluoro-4-Pyrimidinyl)-n-Ethylamine
CAS No.	321529-80-0
Molecular Formula	C6H7ClFN3
Molecular Weight	175.59 g/mol
Synonyms	N-Ethyl-2-chloro-5-fluoropyrimidin-4-amine; 2-Chloro-5-fluoro-N-ethylpyrimidin-4-amine; 4-Amino-2-chloro-5-fluoropyrimidine, N-ethyl derivative; 321529-80-0; 2-Chloro-5-fluoro-4-(ethylamino)pyrimidine; 4-(Ethylamino)-2-chloro-5-fluoropyrimidine
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-5-Fluoro-4-Pyrimidinyl)-n-Ethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.