Description

[D-Trp8]-γ-Msh CAS NO 321351-81-9 is a synthetic peptide analog of γ-melanocyte-stimulating hormone (γ-MSH), featuring a D-tryptophan substitution at position 8. This modification enhances its metabolic stability and receptor selectivity, making it a valuable research tool for studying melanocortin receptor (MCR) signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic, neurological, and dermatological research, as well as in the development of novel therapeutic agents.

Application

• Biomedical Research: A critical tool for investigating the structure-activity relationships (SAR) of melanocortin peptides and their interaction with specific MCR subtypes (MC3R, MC4R, MC5R).
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel therapeutics targeting appetite regulation, energy homeostasis, and inflammatory processes.
• Pharmacological Studies: Used in in vitro and in vivo assays to study the physiological roles of γ-MSH in blood pressure control, natriuresis, and anti-inflammatory effects.
• Neuroscience Research: Applied in studies exploring the central nervous system effects of melanocortins, including their potential role in neuroprotection and behavior.
• Analytical Standard: Employed as a high-purity standard for method development and validation in analytical techniques such as HPLC and mass spectrometry within quality control laboratories.

Basic Information

Product Name	[D-Trp8]-γ-Msh
CAS No.	321351-81-9
Molecular Formula	C₇₇H₁₀₉N₂₁O₂₀S
Molecular Weight	1649.9 g/mol
Synonyms	[D-Tryptophan8]-γ-MSH; γ-MSH (D-Trp8); H-Tyr-Val-Met-Gly-His-Phe-Arg-D-Trp-Asp-Arg-Phe-Gly-OH; γ-Melanocyte Stimulating Hormone (8-D-tryptophan); D-Trp8-Gamma MSH; Melanotropin gamma (8-D-tryptophan)
EINECS	Contact for details

Quality Control

Every batch of [D-Trp8]-γ-Msh is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation to ensure the identity, purity, and consistency required for critical research applications. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, and impurity profiles are available for each lot upon request. Our quality commitment supports compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.