Description

(R)-1-(4-Fluorophenyl)Ethylamine Hydrochloride is a high-purity chiral amine building block essential for the synthesis of enantiomerically pure pharmaceutical intermediates and active ingredients. Its value lies in providing a stereochemically defined, fluorinated aromatic moiety, which is a critical structural feature in modern drug discovery for modulating bioavailability and receptor binding. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of enantiopure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a resolving agent or chiral auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Development: Serves as a building block for creating novel, optically active pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for metal-catalyzed transformations and organocatalysts.
• Chemical Research: Utilized in academic and industrial R&D for exploring new synthetic methodologies and structure-activity relationships (SAR).
• Fine Chemical Production: Integral to the manufacture of specialty chemicals requiring a specific (R)-configured amine with a fluorophenyl group.

Basic Information

Product Name	(R)-1-(4-Fluorophenyl)Ethylamine Hydrochloride
CAS No.	321318-42-7
Molecular Formula	C8H11ClFN
Molecular Weight	175.63 g/mol
Synonyms	(R)-1-(4-Fluorophenyl)ethanamine hydrochloride; (R)-α-Methyl-4-fluorobenzylamine hydrochloride; (R)-4-Fluoro-α-methylbenzylamine hydrochloride; (R)-(-)-1-(4-Fluorophenyl)ethylamine hydrochloride; (1R)-1-(4-Fluorophenyl)ethan-1-amine hydrochloride; (R)-1-(p-Fluorophenyl)ethylamine HCl; (R)-FPEA·HCl; (R)-4-Fluoroamphetamine impurity C hydrochloride (related compound)
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Fluorophenyl)Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.