Description

Benzenemethanamine, 3,4-Difluoro-α-Methyl-, (Alphar)- (9Ci) is a high-purity, chiral fluorinated benzylamine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular architecture, which is essential for introducing specific stereochemistry and fluorine atoms into active pharmaceutical ingredients (APIs) to modulate their metabolic stability, bioavailability, and receptor binding affinity. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents, antiviral drugs, and oncology treatments.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel fluorinated APIs targeting complex diseases.
• Agrochemical Research: Used in the development of advanced, high-efficacy pesticides and herbicides with improved environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic amines used in electronic display technologies.
• Asymmetric Catalysis Ligand Synthesis: Employed in the preparation of sophisticated chiral ligands for enantioselective synthesis.
• Proteomics & Biochemical Research: Utilized as a specialty reagent for labeling and modifying biomolecules in research settings.
• Fluorine Chemistry Development: Acts as a model compound for studying structure-activity relationships (SAR) in fluorinated aromatic systems.

Basic Information

Product Name	Benzenemethanamine, 3,4-Difluoro-α-Methyl-, (Alphar)- (9Ci)
CAS No.	321318-15-4
Molecular Formula	C8H9F2N
Molecular Weight	157.16 g/mol
Synonyms	(αR)-3,4-Difluoro-α-methylbenzylamine; (R)-1-(3,4-Difluorophenyl)ethylamine; (R)-α-Methyl-3,4-difluorobenzylamine; (R)-3,4-Difluoro-α-methylbenzenemethanamine; (R)-1-(3,4-Difluorophenyl)ethan-1-amine; (R)-(-)-1-(3,4-Difluorophenyl)ethylamine; (R)-1-(3,4-Difluorophenyl)ethanamine; (R)-3,4-Difluoro-α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our Benzenemethanamine, 3,4-Difluoro-α-Methyl-, (Alphar)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.