Description

H-Phe-Gln-Gly-Pro-OH is a high-purity synthetic tetrapeptide sequence. This compound is a critical building block in advanced pharmaceutical research and development, particularly for studying protease activity and designing novel therapeutic agents. It is essential for researchers and manufacturers in the fields of peptide-based drug discovery, biochemical assay development, and proteomics. The product is supplied under strict quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a specific substrate for studying the kinetics and inhibition of proteolytic enzymes like dipeptidyl peptidase IV (DPP-IV) and other proline-specific enzymes.
• Drug Discovery: Employed in high-throughput screening (HTS) assays to identify and characterize new enzyme inhibitors for metabolic and inflammatory diseases.
• Proteomics & Peptide Library Synthesis: A valuable component in the construction of focused peptide libraries for structure-activity relationship (SAR) studies.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in peptide analysis.

Basic Information

Product Name	H-Phe-Gln-Gly-Pro-OH
CAS No.	320350-35-4
Molecular Formula	C21H29N5O6
Molecular Weight	447.49 g/mol
Synonyms	L-Phenylalanyl-L-glutaminylglycyl-L-proline; Phe-Gln-Gly-Pro; FQGP-OH; H-Phe-Gln-Gly-Pro; Tetrapeptide FQGP; DPP-IV Substrate Analog; Prolyl Oligopeptidase Substrate; (S)-2-((S)-2-((2-((S)-2-((S)-2-Amino-3-phenylpropanamido)-4-carbamoylbutanamido)acetamido)methyl)pyrrolidine-1-carbonyl)pyrrolidin-1-ium
EINECS	Contact for details

Quality Control

Our H-Phe-Gln-Gly-Pro-OH is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material suitable for use under cGMP guidelines for non-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.