Description

(Val438)-Tyrosinase (432-444) (Human) CAS NO 320341-56-8 is a synthetic peptide fragment corresponding to a specific sequence of the human tyrosinase enzyme. This high-purity biochemical is critical for advanced research into melanogenesis, enzyme kinetics, and autoimmune responses. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on dermatology, oncology, and pigment disorder studies.

Application

• Biochemical Research: Used as a specific antigen or substrate in studies of tyrosinase structure, function, and inhibition mechanisms.
• Immunoassay Development: Serves as a key component in the development of ELISA and other immunoassays for detecting anti-tyrosinase antibodies, relevant in vitiligo and melanoma research.
• Drug Discovery: Employed in high-throughput screening (HTS) platforms to identify and validate novel tyrosinase inhibitors for cosmetic (skin lightening) and therapeutic applications.
• Antigen Standard: Acts as a reference standard for the calibration and quality control of diagnostic tests targeting tyrosinase-related immune responses.
• Cell Biology Studies: Utilized in cellular assays to investigate melanocyte biology, pigment production pathways, and related signaling cascades.

Basic Information

Product Name	(Val438)-Tyrosinase (432-444) (Human)
CAS No.	320341-56-8
Molecular Formula	C68H112N20O21S
Molecular Weight	1553.8 g/mol
Synonyms	Tyrosinase Peptide (432-444), Human; TYR (432-444); Tyrosinase Fragment 432-444; HLA-A*0201-restricted Tyrosinase Peptide; Melanoma Antigen Tyrosinase Peptide; (Val438)TYR(432-444); Peptide Antigen hTyr (432-444, V438); IMDQVPFSV
EINECS	Contact for details

Quality Control

Every batch of (Val438)-Tyrosinase (432-444) (Human) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including reversed-phase HPLC and mass spectrometry, to ensure high purity (>95%) and correct sequence verification. Certificates of Analysis (COA) detailing purity, identity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Sequence	IMDQVPFSV
Molecular Weight	1553.8 ± 1.0 Da
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.