Description

Ethyl 4-Chlorothieno[3,2-D]Pyrimidine-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical sectors who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for biological activity.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• API Manufacturing: Employed in the commercial-scale production of active pharmaceutical ingredients requiring the thienopyrimidine pharmacophore.
• Material Science: Investigated as a potential monomer or precursor for specialty polymers and organic electronic materials.

Basic Information

Product Name	Ethyl 4-Chlorothieno[3,2-D]Pyrimidine-2-Carboxylate
CAS No.	319442-18-7
Molecular Formula	C9H7ClN2O2S
Molecular Weight	242.68 g/mol
Synonyms	Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate; 4-Chlorothieno[3,2-d]pyrimidine-2-carboxylic acid ethyl ester; 2-Carbethoxy-4-chlorothieno[3,2-d]pyrimidine; 319442-18-7; Thieno[3,2-d]pyrimidine-2-carboxylic acid, 4-chloro-, ethyl ester; Ethyl 4-chloro-thieno[3,2-d]pyrimidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chlorothieno[3,2-D]Pyrimidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.