Description

4-Trifluoromethyl-5,6,7,8-Tetrahydro-Quinazoline-2-Thiol is a specialized heterocyclic building block featuring a quinazoline core with a reactive thiol group and a trifluoromethyl substituent. This compound is valued for its unique molecular architecture, which makes it a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals. It is primarily sought after by research institutions and chemical manufacturers in the life sciences sector for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides, leveraging the stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a precursor for ligands and functional molecules in catalysis and advanced material development.
• Chemical Biology Probes: The reactive thiol group allows for conjugation, making it useful for creating probes and biochemical tools.

Basic Information

Product Name	4-Trifluoromethyl-5,6,7,8-Tetrahydro-Quinazoline-2-Thiol
CAS No.	318258-18-3
Molecular Formula	C9H9F3N2S
Molecular Weight	234.24 g/mol
Synonyms	4-(Trifluoromethyl)-5,6,7,8-tetrahydroquinazoline-2-thiol; 5,6,7,8-Tetrahydro-4-(trifluoromethyl)-2-quinazolinethiol; 2-Mercapto-4-trifluoromethyl-5,6,7,8-tetrahydroquinazoline; 4-Trifluoromethyl-5,6,7,8-tetrahydro-2-mercaptoquinazoline; 318258-18-3; 4-Trifluoromethyltetrahydroquinazoline-2-thiol
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-5,6,7,8-Tetrahydro-Quinazoline-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopy, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be stored under an inert atmosphere to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.