Description

4-Trifluoromethyl-6,7Dihydro-5H-Cyclopenta-Pyrimidine-2-Thiol is a high-value heterocyclic building block characterized by its fused cyclopentane-pyrimidine core and reactive thiol and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, offering unique structural and electronic properties that are difficult to replicate. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine and sulfur-containing motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific heterocyclic scaffold.

Basic Information

Product Name	4-Trifluoromethyl-6,7Dihydro-5H-Cyclopenta-Pyrimidine-2-Thiol
CAS No.	318258-17-2
Molecular Formula	C8H7F3N2S
Molecular Weight	220.22 g/mol
Synonyms	2-Mercapto-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine; 4-(Trifluoromethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2-thiol; 2-Thiol-4-trifluoromethyl-6,7-dihydro-5H-cyclopentapyrimidine; 6,7-Dihydro-4-(trifluoromethyl)-5H-cyclopenta[d]pyrimidine-2-thiol; 4-Trifluoromethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2-thiol; CF3-Cyclopentapyrimidine thiol; 318258-17-2
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-6,7Dihydro-5H-Cyclopenta-Pyrimidine-2-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced chemical intermediates. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data (HPLC, GC, NMR) are provided to guarantee traceability and support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be stored away from light. Due to its potential sensitivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.