Description

4-Trifluoromethyl-5,6,7,8-tetrahydroquinazolin-2-ol is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique molecular scaffold, featuring both a trifluoromethyl group and a tetrahydroquinazolinone core, is pivotal for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a privileged scaffold in the synthesis of new herbicides, fungicides, and insecticides, leveraging the metabolic stability imparted by the fluorine atoms.
• Material Science Precursor: Used in the development of specialty chemicals and advanced materials, such as liquid crystals or organic semiconductors.
• Chemical Biology Probe: Employed as a building block for creating molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	4-Trifluoromethyl-5,6,7,8-tetrahydroquinazolin-2-ol
CAS No.	318258-14-9
Molecular Formula	C9H9F3N2O
Molecular Weight	218.18 g/mol
Synonyms	2-Hydroxy-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline; 4-(Trifluoromethyl)-5,6,7,8-tetrahydro-2-quinazolinol; 5,6,7,8-Tetrahydro-4-(trifluoromethyl)quinazolin-2-ol; 4-Trifluoromethyl-5,6,7,8-tetrahydroquinazolin-2(1H)-one (tautomer); TFTHQ; 318258-14-9
EINECS	Contact for details

Quality Control

Every batch of 4-Trifluoromethyl-5,6,7,8-tetrahydroquinazolin-2-ol is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.