Description

Amyloid β-Protein (42-1) Trifluoroacetate is a synthetic peptide fragment corresponding to the N-terminal 42 amino acid residues of the amyloid β-protein, provided as the trifluoroacetate salt. This compound is a critical research reagent for studying the molecular mechanisms underlying Alzheimer's disease and other amyloid-related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers focused on neurodegenerative disease research, drug discovery, and biomarker assay development.

Application

• Alzheimer's Disease Research: Used as a standard or substrate in studies investigating amyloid-beta aggregation, neurotoxicity, and plaque formation.
• Drug Discovery & Screening: Serves as a key target compound in high-throughput screening (HTS) assays to identify potential therapeutic inhibitors of amyloid-beta aggregation.
• Biomarker Assay Development: Employed in the development and calibration of immunoassays (ELISA, Western Blot) and other diagnostic tests for detecting amyloid-beta peptides.
• Structural Biology Studies: Utilized in NMR, X-ray crystallography, and other biophysical techniques to elucidate the structure and folding dynamics of amyloid-beta peptides.
• Cell Culture & In Vitro Models: Applied to induce amyloid-related cytotoxicity in neuronal cell cultures to model disease mechanisms and test neuroprotective compounds.
• Antibody Production & Validation: Acts as an immunogen for generating specific antibodies or as a reference standard for validating antibody specificity.

Basic Information

Product Name	Amyloid β-Protein (42-1) Trifluoroacetate
CAS No.	317366-82-8
Molecular Formula	C203H311N55O60S • xC2HF3O2
Molecular Weight	4514.1 g/mol (free base)
Synonyms	Amyloid β-Protein (1-42) TFA salt; Aβ42; Aβ(1-42); β-Amyloid (1-42); Amyloid β-Peptide (1-42); Amyloid Precursor Protein (672-713); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH (TFA salt)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (42-1) Trifluoroacetate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity, correct sequence, and batch-to-batch consistency, which are critical for reproducible research outcomes. Quality is verified by multiple orthogonal methods including HPLC, MS, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with each batch to support your compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥95%
Peptide Content	≥70% (by weight)
Solvent Content (TFA)	≤15% (by weight)
Water Content (KF)	≤5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.