Description

(Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (Human) CAS NO 313988-89-5 is a synthetic, modified analog of human pancreatic polypeptide (hPP), engineered with specific amino acid substitutions to enhance its stability and biological activity. This high-purity peptide is critical for advanced research in endocrinology and metabolic disorders, serving as a potent tool for studying pancreatic function and receptor interactions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for diabetes, obesity, and gastrointestinal diseases.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating the role of pancreatic polypeptide in appetite regulation, energy homeostasis, and pancreatic secretion.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the development of peptide-based therapeutics targeting Y4 and Y5 receptors for metabolic diseases.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, ELISA tests, and receptor binding studies.
• Academic & Clinical Studies: Facilitates fundamental research into neuroendocrine signaling pathways and their implications in diabetes, obesity, and pancreatic cancer.
• Quality Control & Standardization: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring batch-to-batch consistency in peptide manufacturing.

Basic Information

Product Name	(Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (Human)
CAS No.	313988-89-5
Molecular Formula	C201H317N61O58S
Molecular Weight	4531.1 g/mol (monoisotopic)
Synonyms	Modified Human Pancreatic Polypeptide; hPP Analog; [Aib32]-hPP; Pancreatic Polypeptide (1-36), human, Gly1, Ser3,22, Gln4,34, Thr6, Arg19, Tyr21, Ala23,31, Aib32-; PPY (1-36) (human) analog; CAS 313988-89-5; Y4/Y5 Receptor Ligand
EINECS	Contact for details

Quality Control

Every batch of our (Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (Human) is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our processes are designed to meet the stringent requirements of GMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the lyophilized powder desiccated. After reconstitution, aliquot and store frozen at -70°C to -80°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.