Description

Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (Human) is a synthetic, high-purity peptide analog designed for advanced biochemical and pharmacological research. This compound is crucial for studying the structure-activity relationships and signaling pathways of neuropeptide Y (NPY) and pancreatic polypeptide (PP) receptors. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and biotechnology companies engaged in metabolic, cardiovascular, and neurological disorder research.

Application

• Biochemical Research: Used as a selective ligand to investigate the binding affinity and functional activity of NPY/PP receptor subtypes (Y1, Y2, Y4, Y5).
• Pharmacology Studies: Serves as a key tool in preclinical studies for developing novel therapeutics targeting appetite regulation, anxiety, and blood pressure.
• Structure-Activity Relationship (SAR) Analysis: The incorporation of non-natural amino acids (Ala31, Aib32) makes it an essential probe for understanding peptide stability and receptor interaction motifs.
• In Vitro Assay Development: Employed in cell-based assays and competitive binding experiments to screen for receptor agonists or antagonists.
• Metabolic Disorder Research: Applied in studies focusing on energy homeostasis, food intake, and obesity-related pathways.
• Neuroscience Research: Utilized to explore the role of NPY systems in stress responses, emotional behavior, and seizure activity.

Basic Information

Product Name	Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (Human)
CAS No.	313988-70-4
Molecular Formula	C152H238N46O43
Molecular Weight	~3350.8 g/mol
Synonyms	PP(1-17)-[Ala31,Aib32]-NPY(18-36); [Ala31,Aib32]PP/NPY(1-36); Human PP/NPY Hybrid Peptide; NPY/PP Receptor Probe; (Ala31, α-Aminoisobutyric acid32) Pancreatic Polypeptide/Neuropeptide Y Fragment; CAS 313988-70-4; PP(1-17),NPY(18-36) (Ala31,Aib32) analog
EINECS	Contact for details

Quality Control

Our high-purity peptide is manufactured under controlled conditions to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, amino acid analysis, and peptide content are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere after opening and allow it to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.