Description

Fmoc-Alg(Boc)2-Oh CAS NO 313232-63-2 is a protected amino acid derivative, specifically an Fmoc-protected L-α-aminoadipic acid with both carboxylic acid side chains protected as tert-butyl esters. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a dicarboxylic acid residue into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of complex peptides containing L-α-aminoadipic acid.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and production of peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation & Labeling: Used to introduce a reactive carboxylic acid handle (after deprotection) for coupling with amines, alcohols, or other functional groups in bioconjugation chemistry.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Chemical Biology Research: Facilitates the study of protein-protein interactions and enzyme mechanisms by allowing site-specific incorporation of modified amino acids.
• Custom Peptide Service Providers: A standard reagent for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Alg(Boc)2-Oh
CAS No.	313232-63-2
Molecular Formula	C₃₂H₄₁NO₈
Molecular Weight	567.67 g/mol
Synonyms	Fmoc-L-α-aminoadipic acid bis(tert-butyl ester); N-(9-Fluorenylmethoxycarbonyl)-L-α-aminoadipic acid di-tert-butyl ester; Fmoc-Aad(OtBu)-OH; Fmoc-2-Aminoadipic acid(OtBu)₂-OH; Nα-Fmoc-L-2-aminoadipic acid 1,6-di-tert-butyl ester; Fmoc-Aad(OtBu)₂-OH; Fmoc-α-Aminoadipic acid bis(tert-butyl) ester
EINECS	Contact for details

Quality Control

Our Fmoc-Alg(Boc)2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.