Description

Leptin (126-140) (Human) CAS NO 313220-09-6 is a synthetic peptide fragment corresponding to amino acids 126-140 of the human leptin protein. This high-purity peptide is a critical research tool for studying the structure, function, and signaling mechanisms of leptin, a key hormone in regulating energy balance and metabolism. It is essential for pharmaceutical R&D, academic research, and diagnostic development focused on obesity, diabetes, and metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and antigen in studies investigating leptin's role in appetite regulation, energy homeostasis, and neuroendocrine function.
• Antibody Production: Serves as an immunogen for generating specific polyclonal or monoclonal antibodies against the leptin protein for immunoassay development.
• Diagnostic Development: Employed in the calibration and validation of ELISA and other immunoassay kits designed to detect and quantify leptin levels in biological samples.
• Signal Transduction Studies: Utilized to map receptor binding sites and study the interaction between leptin and its receptor (LEPR) to understand downstream signaling pathways.
• Pharmaceutical Screening: Acts as a tool compound in high-throughput screening assays to identify potential leptin mimetics or receptor modulators for therapeutic development.
• Metabolic Disorder Research: Critical for in vitro and ex vivo experiments aimed at understanding leptin resistance, a hallmark of obesity and type 2 diabetes.

Basic Information

Item	Details
Product Name	Leptin (126-140) (Human)
CAS No.	313220-09-6
Molecular Formula	C78H122N22O21S
Molecular Weight	1744.0 g/mol
Synonyms	Human Leptin Fragment 126-140; Leptin (126-140); Leptin Human (126-140); LEPrp126-140; Obese Protein (126-140) (Human); LEP (126-140); Leptin Peptide (126-140); Obesity Hormone Fragment
EINECS	Contact for details

Quality Control

Every batch of Leptin (126-140) (Human) is manufactured and analyzed under strict quality management systems. We guarantee high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, MS, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with each shipment to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider aliquoting to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.