Description

2-n-Fmoc-Amino-3-(2-n-Boc-Amino-Pyrrolidinyl)Propionic Acid is a sophisticated, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for enabling the precise, sequential assembly of complex peptides and peptidomimetics, particularly those containing constrained proline-like structures. It is an essential building block for researchers and manufacturers in pharmaceutical development, specifically for creating novel therapeutic peptides, protease inhibitors, and drug candidates targeting GPCRs and other protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc/Boc-protected intermediate for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: Used to incorporate a constrained pyrrolidine scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core component in the design of inhibitors for enzymes like HIV protease, HCV protease, and thrombin.
• GPCR-Targeted Therapeutics: Employed in the synthesis of peptide ligands for G-protein coupled receptors involved in various disease pathways.
• Chemical Biology Probes: Used to create labeled or modified peptides for studying protein function and interaction mechanisms.
• Custom Peptide Services: A high-value raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	2-n-Fmoc-Amino-3-(2-n-Boc-Amino-Pyrrolidinyl)Propionic Acid
CAS No.	313052-08-3
Molecular Formula	C28H33N3O6
Molecular Weight	507.58 g/mol
Synonyms	Fmoc-(2S,2'S)-2-Amino-3-(2'-{[(tert-butoxy)carbonyl]amino}pyrrolidin-1-yl)propanoic Acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[(2S)-2-[(tert-butoxycarbonyl)amino]-1-pyrrolidinyl]propanoic Acid; Nα-Fmoc-Nδ-Boc-(S)-2,3-Diaminopropionic Acid Pyrrolidine Amide; Boc-Dpr(Fmoc)-Pro-OH derivative; Fmoc-Dap(Boc)-ψ[CH2-N(Pro)]
EINECS	Contact for details

Quality Control

Every batch of 2-n-Fmoc-Amino-3-(2-n-Boc-Amino-Pyrrolidinyl)Propionic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to support cGMP-compliant applications in drug development. Comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.