Description

n-α-Fmoc-β-(1-Boc-Piperidin-4-Yl)-D,L-Alanine CAS NO 313052-02-7 is a specialized, dual-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for constructing complex peptide sequences, particularly those requiring the incorporation of constrained, non-natural amino acids to modulate biological activity and stability. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-strategy synthesis of complex peptides, enabling the controlled introduction of a piperidine-constrained alanine analogue.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide drugs targeting GPCRs, enzymes, and other biological targets where conformational restriction is beneficial.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of peptide mimetics for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the creation of labeled peptides for imaging, diagnostic assays, and targeted drug delivery systems.
• Academic Research: Employed in biochemical and structural biology studies to investigate protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	n-α-Fmoc-β-(1-Boc-Piperidin-4-Yl)-D,L-Alanine
CAS No.	313052-02-7
Molecular Formula	C29H36N2O6
Molecular Weight	508.61 g/mol
Synonyms	Fmoc-β-(1-Boc-piperidin-4-yl)-D,L-alanine; N-α-Fmoc-N-β-(1-Boc-4-piperidyl)-D,L-alanine; 1-Boc-4-piperidyl-D,L-alanine, N-α-Fmoc derivative; Fmoc-β-(N-Boc-piperidin-4-yl)alanine; (R,S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-((tert-butoxy)carbonyl)piperidin-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-α-Fmoc-β-(1-Boc-Piperidin-4-Yl)-D,L-Alanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.