Description

Fmoc-(+/-)-cis-3-Aminocyclohexane-1-Carboxylic Acid CAS NO 312965-05-2 is a protected, non-proteinogenic amino acid derivative featuring a cyclohexane backbone, widely utilized as a key chiral building block in organic synthesis. Its primary value lies in enabling the controlled introduction of a constrained, alicyclic structure into peptide chains, which is crucial for modulating the conformational and pharmacological properties of novel compounds. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical R&D, particularly in the development of peptide-based therapeutics, peptidomimetics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical Fmoc-protected amino acid for the automated synthesis of complex peptides containing constrained cyclohexyl amino acid residues.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, alicyclic motifs that mimic natural peptide turns and secondary structures, enhancing metabolic stability and receptor selectivity.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse compound libraries aimed at high-throughput screening for new biological targets.
• Chemical Biology & Probe Development: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme mechanisms and protein-protein interactions.
• API Intermediate Synthesis: Acts as a chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) with specific conformational requirements.
• Academic & Industrial Research: A fundamental reagent for methodological development in asymmetric synthesis and novel peptide coupling strategies.

Basic Information

Product Name	Fmoc-(+/-)-cis-3-Aminocyclohexane-1-Carboxylic Acid
CAS No.	312965-05-2
Molecular Formula	C₂₂H₂₃NO₄
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-cis-3-Amino-1-cyclohexanecarboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-cis-3-aminocyclohexanecarboxylic Acid; Fmoc-3-Acc-OH (cis); Fmoc-cis-ACHC-OH; (1r,3s)- and (1s,3r)-1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-cyclohexanecarboxylic Acid; N-Fmoc-cis-3-aminocyclohexane-1-carboxylic acid; Fmoc-cis-3-Ac6c-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(+/-)-cis-3-Aminocyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.