Description

3-Chloro-5-Phenyl-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid (Saltdata: Free) is a high-value, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring potent and selective small-molecule candidates. It is primarily sought by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of complex drug molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique pyrazolo[1,5-a]pyrimidine scaffold.
• Chemical Biology Probes: Serves as a precursor for developing selective enzyme inhibitors or receptor modulators for biological pathway investigation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for advanced studies in heterocyclic chemistry and drug discovery methodologies.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes from laboratory to pilot and commercial production.

Basic Information

Item	Details
Product Name	3-Chloro-5-Phenyl-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid (Saltdata: Free)
CAS No.	312699-22-2
Molecular Formula	C15H11ClF3N3O2
Molecular Weight	357.71 g/mol
Synonyms	3-Chloro-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 312699-22-2; 3-Chloro-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 2H-Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 3-chloro-4,5,6,7-tetrahydro-5-phenyl-7-(trifluoromethyl)-; 3-Chloro-5-phenyl-7-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 3-Chloro-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. The material undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR, and mass spectrometry for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with ICH guidelines for stability and impurity profiling upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.