Description

Fmoc-α-Methyl-L-Leucine CAS NO 312624-65-0 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing steric hindrance and conformational constraints into peptide chains, enabling the development of novel bioactive molecules with enhanced stability and specificity. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the development of peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used to incorporate α-methyl-leucine residues into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Employed in the design and synthesis of constrained peptide analogs to improve metabolic stability, receptor selectivity, and bioavailability.
• Peptidomimetics Development: Serves as a crucial scaffold for creating non-natural peptide mimics that resist enzymatic degradation.
• Bioconjugation and Probe Synthesis: Used in the preparation of labeled peptides for imaging, diagnostic assays, and target identification studies.
• Academic and Industrial Research: A fundamental reagent in laboratories studying protein-protein interactions, enzyme inhibitors, and novel therapeutic modalities.

Basic Information

Product Name	Fmoc-α-Methyl-L-Leucine
CAS No.	312624-65-0
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-α-Me-L-Leu-OH; N-(9-Fluorenylmethoxycarbonyl)-α-methyl-L-leucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methylpentanoic acid; Fmoc-α-Methylleucine; Fmoc-Aml-OH; N-α-Fmoc-α-methyl-L-leucine; Fmoc-L-α-methylleucine
EINECS	Contact for details

Quality Control

Our Fmoc-α-Methyl-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.